Well, the uC on the TinyG board should be able to send/receive ISP commands, right? So it should be possible to send commands from the Espruino to the TinyG uC.
Maybe it requires some programming on the TinyG uC to recognise and interpret commands from the Espruino, but in theory it sounds possible.
Some clarification of the project I’m working on:
I have an Espruino controlling several sensors and buttons. When I press one of the buttons, the Espruino needs to send a command to the TinyG, telling it to move to a location (specified in the command).
So I have a start button to run a premade program, a reset button to home, an emergency button to stop all processes, etc.