I sort of thought so, comparing forums.
I have not had the time to dig into the details as you have, but have seen folks have to (try to) replace QFPs in tinyGs due to an oops with wiring, etc. So my current quick solution is to raise the flag high and let them seek their own understanding.
Given the ‘almost same’ UNO vs DUE interfaces, I bet a whole lot of DUEs are being compromised by 5V shields of all types.
Gaups looks cool – now on my list of things for folks to consider.