I don’t recall seeing anyone trying this and have no direct experience.
Chrome browser, on Winx, Linux and MACOS has always been the defacto preferred browser for the GUI. Firefox usually works well as well as Safari, Win IE not so much.
The critical issue could be compatibility with the serial port json server – SPJS. It is compiled for X86 machines running Windows, Linux and MAC as well as RasPi running on ARM.
Do you have a Chromebook you propose to use, or is your target X86?
If I recall correctly, a target for ChromeOS was Web interface for highly portable, lower power machines.
SPJS handles all the low level heavy duty I/O, can be marginal on overly ‘thin’ clients. For example, SPJS was too much load for a RasPi !, but runs well on the more recent RasPi 2.
You might query here: